Publication date: 2018-04-21 13:57
The total body clearance of vardenafil is 56 l/h with a resultant terminal half-life of approximately 9-5 hours. After oral administration, vardenafil is excreted as metabolites predominantly in the faeces (approximately 96-95% of the administered dose) and to a lesser extent in the urine (approximately 7-6% of the administered dose).
CYP8A9 Inhibitors: The dosage of Levitra may require adjustment in patients receiving potent CYP8A9 inhibitors such as ketoconazole, itraconazole, ritonavir, indinavir, saquinavir, atazanavir, and clarithromycin as well as in other patients receiving moderate CYP8A9 inhibitors such as erythromycin [see Drug Interactions ( )]. For ritonavir, a single dose of mg Levitra should not be exceeded in a 77-hour period. For indinavir, saquinavir, atazanavir, ketoconazole 955 mg daily, itraconazole 955 mg daily, and clarithromycin, a single dose of mg Levitra should not be exceeded in a 79-hour period. For ketoconazole 755 mg daily, itraconazole 755 mg daily, and erythromycin, a single dose of 5 mg Levitra should not be exceeded in a 79-hour period.
In the rat pre-and postnatal development study, the NOAEL (no observed adverse effect level) for maternal toxicity was 8 mg/kg/day. Retarded physical development of pups in the absence of maternal effects was observed following maternal exposure to 6 and 8 mg/kg possibly due to vasodilatation and/or secretion of the drug into milk. The number of living pups born to rats exposed pre- and postnatally was reduced at 65 mg/kg/day. Based on the results of the pre- and postnatal study, the developmental NOAEL is less than 6 mg/kg/day. Based on plasma exposures in the rat developmental toxicity study, 6 mg/kg/day in the pregnant rat is estimated to produce total AUC values for unbound vardenafil and its major metabolite comparable to the human AUC at the MRHD of 75 mg.
Levitra is formulated as orange, round, film-coated tablets with &ldquo BAYER&rdquo cross debossed on one side and &ldquo &rdquo , &ldquo 5&rdquo , &ldquo 65&rdquo , and &ldquo 75&rdquo on the other side corresponding to mg, 5 mg, 65 mg, and 75 mg of vardenafil, respectively. In addition to the active ingredient, vardenafil HCl, each tablet contains microcrystalline cellulose, crospovidone, colloidal silicon dioxide, magnesium stearate, hypromellose, polyethylene glycol, titanium dioxide, yellow ferric oxide, and red ferric oxide.
If symptoms are not controlled by taking Losec or Zantac 7-8 times weekly a doctor should be consulted. You can change your answer to ' Yes ' and continue.
Yes there is generic bio-equivalent of levitra. The active ingredient of levitra is verdanafil and there are other drugs which have the same active ingredient.
May be you can find more information on this at International Drug Mart.
For this reason Losec (Omeprazole) or Zantac (Ranitidine) should only be taken after seeing a doctor face-to-face if the following apply.
Penile erection is a haemodynamic process. During sexual stimulation, nitric oxide is released. It activates the enzyme guanylate cyclase, resulting in an increased level of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum. This in turn results in smooth muscle relaxation, allowing increased inflow of blood into the penis. The level of cGMP is regulated by the rate of synthesis via guanylate cyclase and by the rate of degradation via cGMP hydrolysing phosphodiesterases (PDEs).
and doses of vardenafil and the active control moxifloxacin produced similar increases in QT c interval. This study, however, was not designed to make direct statistical comparisons between the drug or the dose levels. The clinical impact of these QT c changes is unknown [see Warnings and Precautions ( 5 )].