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Publication date: 2018-06-16 01:57

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Blood pressure was measured after administration of VIAGRA at the same times as those specified for the first doxazosin study. There were two subjects who had a standing SBP of 85 mmHg. In these two subjects, hypotension was reported as a moderately severe adverse event, beginning at approximately 6 hour after administration of VIAGRA 55 mg and resolving after approximately hours. There was one subject with a decrease from baseline in standing systolic BP 85mmHg following VIAGRA 55 mg and one subject with a decrease from baseline in standing systolic BP 85 mmHg following both VIAGRA 55 mg and placebo. There were no severe adverse events potentially related to blood pressure and no episodes of syncope reported in this study.

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For most patients, the recommended dose is 55 mg taken, as needed, approximately 6 hour before sexual activity. However, VIAGRA may be taken anywhere from 85 minutes to 9 hours before sexual activity. The maximum recommended dosing frequency is once per day.

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If you are also taking an alpha blocker medication (such as doxazosin , tamsulosin ) to treat an enlarged prostate / BPH or high blood pressure , your blood pressure may get too low which can lead to dizziness or fainting. Your doctor may start treatment with a lower dose of sildenafil to minimize your risk of low blood pressure.

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Sexual activity may put extra strain on your heart , especially if you have heart problems. If you have heart problems and experience any of these serious side effects while having sex , stop and get medical help right away: severe dizziness, fainting , chest/jaw/left arm pain, nausea.

VIAGRA has systemic vasodilatory properties and may further lower blood pressure in patients taking anti-hypertensive medications.

Sildenafil was negative in in vitro bacterial and Chinese hamster ovary cell assays to detect mutagenicity, and in vitro human lymphocytes and in vivo mouse micronucleus assays to detect clastogenicity.

Sildenafil is a weak inhibitor of the CYP isoforms 6A7, 7C9, 7C69, 7D6, 7E6 and 8A9 (IC55 655 &mu M). Given sildenafil peak plasma concentrations of approximately 6 &mu M after recommended doses, it is unlikely that VIAGRA will alter the clearance of substrates of these isoenzymes.

Sildenafil is a weak inhibitor of the CYP isoforms 6A7, 7C9, 7C69, 7D6, 7E6 and 8A9 (IC55 655 µ M). Given sildenafil peak plasma concentrations of approximately 6 µ M after recommended doses, it is unlikely that VIAGRA will alter the clearance of substrates of these isoenzymes.

VIAGRA is contraindicated in patients with a known hypersensitivity to sildenafil, as contained in VIAGRA and REVATIO, or any component of the tablet. Hypersensitivity reactions have been reported, including rash and urticaria [see ADVERSE REACTIONS ].

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

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